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ADC-Linkers

The ADC linker is one of the three main components of antibody drug conjugates (ADCs), linking the antibody to the effective drug (payload) through chemical bonds. ADC linkers play a key role in determining the overall success of antibody drug conjugates. One of the major challenges in developing safe and effective ADC drugs is to assemble an ideal chemical linker between the cytotoxic payload and the mAb. Well-designed ADC linkers can help the selective delivery of antibodies at the tumor site and the accurate release of cytotoxic drugs.

4-[3-[bis(4-methoxyphenyl)-phenylmethoxy]propoxy]-4-oxobutanoic acid,triethylamine salt
4-[3-[bis(4-methoxyphenyl)-phenylmethoxy]propoxy]-4-oxobutanoic acid,triethylamine salt
CM1035085
1,3-di-(4,4'-dimethoxyltrityl)-2-Succinate-Glycerol,triethylamine salt
1,3-di-(4,4
CM1035090
(2S)-6-[[rel-(1R,8S,9s)-9-bicyclo[6.1.0]non-4-ynyl]methoxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid
(2S)-6-[[rel-(1R,8S,9s)-9-bicyclo[6.1.0]non-4-ynyl]methoxycarbonylamino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid
CM1076056
1493802-95-1
[rel-(1S,8R,9r)-9-bicyclo[6.1.0]non-4-ynyl]methyl N-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]carbamate
[rel-(1S,8R,9r)-9-bicyclo[6.1.0]non-4-ynyl]methyl N-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]carbamate
CM1076057
1951439-51-2
(2S)-2-[[(2S)-2-[3-[2-[2-[2-[2-[2-[2-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoylamino]-3-methyl-butanoyl]amino]propanoic acid
(2S)-2-[[(2S)-2-[3-[2-[2-[2-[2-[2-[2-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoylamino]-3-methyl-butanoyl]amino]propanoic acid
CM1076368
1800456-99-8
4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexanecarboxamide
4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexanecarboxamide
CM1077168
104676-09-7
5-amino-1-(2-azatricyclo[10.4.0.0⁴⁹]hexadeca-1(12),4(9),5,7,13,15-hexaen-10-yn-2-yl)pentan-1-one
5-amino-1-(2-azatricyclo[10.4.0.0⁴⁹]hexadeca-1(12),4(9),5,7,13,15-hexaen-10-yn-2-yl)pentan-1-one
CM1077235
2401876-29-5
9-bicyclo[6.1.0]non-4-ynylmethyl N-[2-[2-[2-[(2-aminooxyacetyl)amino]ethoxy]ethoxy]ethyl]carbamate
9-bicyclo[6.1.0]non-4-ynylmethyl N-[2-[2-[2-[(2-aminooxyacetyl)amino]ethoxy]ethoxy]ethyl]carbamate
CM1077259
2253965-14-7
(2R,6S,6aS)-6-triphenylsilyloxy-1,2,4,5,6,6a-hexahydropentalen-2-ol
(2R,6S,6aS)-6-triphenylsilyloxy-1,2,4,5,6,6a-hexahydropentalen-2-ol
CM1077268
2410639-39-1
Poly(oxy-1,2-ethanediyl),α-[2-[[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]ethyl]-ω-[3-[(2,5-dioxo-1-pyrrolidinyl)oxy]-3-oxopropoxy]-
Poly(oxy-1,2-ethanediyl),α-[2-[[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]ethyl]-ω-[3-[(2,5-dioxo-1-pyrrolidinyl)oxy]-3-oxopropoxy]-
CM1077282
326003-46-7
9-bicyclo[6.1.0]non-4-ynylmethyl N-[4-(2-cyanoethynyl)phenyl]carbamate
9-bicyclo[6.1.0]non-4-ynylmethyl N-[4-(2-cyanoethynyl)phenyl]carbamate
CM1077284
1644038-97-0
(6S,6aS)-6-triphenylsilyloxy-4,5,6,6a-tetrahydro-1H-pentalen-2-one
(6S,6aS)-6-triphenylsilyloxy-4,5,6,6a-tetrahydro-1H-pentalen-2-one
CM1077295
2410639-38-0
1-[3-(morpholin-4-yl)propyl]-2,5-dihydro-1H-pyrrole-2,5-dione
1-[3-(morpholin-4-yl)propyl]-2,5-dihydro-1H-pyrrole-2,5-dione
CM1077297
46506-18-7