• Nucleoside Drugs and APIs: for the Teatment of Hepatitis B

    Nucleoside Drugs and APIs: for the Teatment of Hepatitis B

    The nucleoside drugs has been instrumental in the treatment of chronic hepatitis B. In the past two decades, research has continued to develop and nucleoside analogues have emerged, and there are now five nucleoside analogues, including lamivudine, adefovir, tipifovir, entecavir and tenofovir, and people have gained a deeper understanding and more experience in the antiviral treatment of hepatitis B. With the end of the protection period of various original drugs, the research and development of generic drugs in China has entered a brand new stage, and clinicians and patients have more choices compared with the past.   CHEMENU is a manufacturer of nucleoside and nucleotide pharmaceutical ingredients, and we have various intermediates for sale to provide basic materials for the research of nucleoside drugs in the world. Read on to learn more about how nucleosides are therapeutic.         The importance of treatment Antiviral treatment for chronic hepatitis B is a global consensus. Although hepatitis B virus does not directly destroy liver cells, liver cells are the host site of hepatitis B virus, and once the body's immune system recognizes hepatitis B virus, an immune-mediated response is bound to occur, causing liver cell damage, abnormal liver function, and even cirrhosis, liver failure, and possibly liver cancer. Therefore, various guidelines from around the world emphasize the necessity and importance of antiviral therapy for chronic hepatitis B.   There are two major categories of clinically applied anti-hepatitis B virus drugs, one is nucleoside analogues and the other is a-interferon, the latter has a tendency to gradually decrease in clinical application because of the large side effects and inconvenient administration, and the more common application is nucleoside analogues.     2'-O-(2-Methoxyethyl)guanosine CAS:473278-54-5     Nucleoside drug mechanism A nucleoside analogue is a nucleoside whose structure has been artificially modified, and this modification is usually performed on pentoses. The bases corresponding to lamivudine, telbivudine and entecavir are cytosine, thymine and guanine, respectively, and the bases corresponding to adefovir and tenofovir are both adenine. The antiviral mechanism of nucleoside analogues is to block the replication of virus by inhibiting the activity of HBV DNA polymerase. Because of the high similarity between the nucleoside structure of the drug and the viral polymerase, they can competitively bind to the viral polymerase, thus reducing the enzyme activity and terminating the extension of the viral DNA chain.     Rational selection of drugs The guidelines for the prevention and treatment of hepatitis B developed by the American College of Hepatology, the European College of Hepatology and the Asia Pacific Society of Hepatology all put forward the concept of "first-line drugs", i.e., first-line drugs should be preferred in antiviral therapy, and the recommended first-line drugs are entecavir, tenofovir and pegylated interferon.   People should put safety and efficacy in the first place when choosing drugs, and be guided by guidelines, taking into account price, health insurance and accessibility of drugs. In terms of drug safety, the focus should be on side effects and teratogenicity. China has conducted quality consistency evaluation of approved generic drugs in batches according to the principle of consistent quality and efficacy with the original drug, which provides new help for our drug selection.     Antiviral therapy for chronic hepatitis B is the key to treatment, and nucleoside analogues are effective antiviral drugs. Please contact CHEMENU to get more products and the quote.  

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    Jan.19.2022

  • 2022 LINKCHEM ANNUAL EVENT| INNOVATION-DRIVEN BRIGHT FUTURE

    2022 LINKCHEM ANNUAL EVENT| INNOVATION-DRIVEN BRIGHT FUTURE

    Chemenu, founded in 2009, provides a wide variety of organic compounds and offers exclusive development for advanced intermediates. We manufacture building blocks, intermediates and novel compounds.   Our goal is to support research projects for pharmaceutical and biotech companies, drug discovery centers, academic institutions and other research organizations worldwide.         Part of the Linkchem Group, Chemenu can also supply CRO, CMO, CDMO services for R&D, process and commercial production. We are proud to be a reliable partner for our clients all over the world.       On the occasion of New Year's Day 2022, our company held a grand annual meeting ceremony. The auditorium was beautifully decorated with flashing lights.               We held an award ceremony. Partners with outstanding achievements in 2021 were appreciated, including contribution awards and team awards, and we wished our employees to continue their efforts in the coming year.         At the end of the annual meeting, we had a talent show session. Singing, dancing, drama, everyone enjoyed having fun.         Chemenu will keep on going and do our best to research new products and serve our customers.    

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    Jan.13.2022

  • What Are the Characters of Pesticide Intermediates?

    What Are the Characters of Pesticide Intermediates?

    Intermediates are a very important fine chemical product, essentially a class of "semi-finished products", which are intermediate products for the production of certain products. It can save cost and is widely used in the synthesis of pharmaceuticals, pesticides, coatings, dyes and fragrances. In the pharmaceutical field, intermediates are an important link in the pharmaceutical industry chain, and today, CHENENU mainly talk about pesticide intermediates.   What is pesticide Pesticides are chemical synthetics or mixtures of one substance or several substances composed of biological or other natural substances and their preparations used to prevent, destroy or control agricultural, forest, disease, insect, grass and other pests and purposefully regulate the growth of plants and insects. Pyrazole substances are common here. Broadly speaking, pesticides are divided into crop protection pesticides and non-crop protection pesticides. Crop protection pesticides are mainly divided into herbicides, insecticides, fungicides and plant growth regulators, etc., which are mainly used for agricultural protection; non-crop protection pesticides mainly include rodenticides, insect repellents, sanitary mosquito supplies, etc.       Synthesis process The synthesis of pharmaceutical intermediates is generally carried out in the reactor, and the generated intermediates should be separated and purified, which is usually achieved through extraction technology. And chloroform extraction of pesticide intermediates is a common operating unit in chemical enterprises, and the traditional operating process generally uses distillation tower operation. This operation process is complex, with low extraction efficiency and high power consumption, so most enterprises began to make technical changes to choose a more efficient process for the operation. Solvent extraction method began to become the main operating unit of the extraction section in the chemical industry. This method is simple to operate, with high extraction efficiency and cheap and easy to obtain extraction agent, while the extraction agent can be recycled, effectively saving the comprehensive input cost.   4-Methyl-L-phenylalanine     The role of intermediates The pesticide industry is at the end of the chemical industry chain and belongs to the fine chemical industry. Under the contradiction of global population growth and decreasing arable land, the massive use of pesticides to increase the yield per unit area is an important way to solve the food problem. Different insecticides require different intermediates in the production process. The products resulting from the processing of agricultural raw materials are also intermediates, which can be understood as synergists, also known as organic intermediates. Initially, they are intermediates produced in the process of synthesizing chemical products such as fragrances, dyes, resins, drugs, plasticizers, rubber accelerators, etc. from coal tar or petroleum products.       Pesticides are important production materials in agricultural production and play an extremely important role in controlling pests, diseases and weeds, stabilizing and improving crop yields. We provide custom synthesis/manufacturing including multi-step organic synthesis, process development, pilot and commercial manufacturing, and CMC services. Please contact us if you need to buy them.    

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    Jan.05.2022

  • The CDMO Demand behind the ADC Drug Boom

    The CDMO Demand behind the ADC Drug Boom

    IUPAC Name:2,5-dioxopyrrolidin-1-yl 2-iodoacetate

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    Dec.17.2021

  • The Importance of Steroid Hormones in the API Industry

    The Importance of Steroid Hormones in the API Industry

    Since the 1990s, the sales of steroid hormone drugs in the international market have been increasing at a rate of 10%~15% per year. At present, steroid drugs are the second largest class of chemical drugs after antibiotics, and China has taken the development of new resources of steroid hormone drugs as one of the directions and priorities of the recent development of the pharmaceutical industry. The export of hormone APIs and intermediates has become an important variety of Chinese APIs to the world.

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    Dec.02.2021