Pyridine is a six-membered heterocyclic compound containing one nitrogen heteroatom. Pyridine and piperidine are the most frequently occurring heterocyclic building blocks in drug molecules. According to incomplete statistics, there are currently more than 180 drugs containing pyridine or piperidine structure that have been marketed, nearly 1/5 of the drugs approved for marketing in recent years contain these two structures.
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Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell.
Phthalazine is a heterocyclic compound with the molecular formula C8H6N2 composed of a benzene ring fused with a pyridazine ring. Phthalazine and its derivatives do not exist in nature. Phthalazines are used as starting materials for organic synthesis. Studies have found that phthalazine has a variety of physiological activities, such as anti-cancer, antibacterial, anti-inflammatory and so on. The synthesis of phthalazine compounds with novel structures and better biological activities has become a research hotspot in recent years.
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