製品名:3-Bromoimidazo[1,5-a]pyridine-1-carboxylic acid

IUPAC Name:3-bromoimidazo[1,5-a]pyridine-1-carboxylic acid

CAS番号:1119512-48-9
分子式:C8H5BrN2O2
純度:95%+
カタログ番号:CM151307
分子量:241.04

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製品詳細

CAS番号:1119512-48-9
分子式:C8H5BrN2O2
融点:-
SMILESコード:O=C(C1=C2C=CC=CN2C(Br)=N1)O
密度:
カタログ番号:CM151307
分子量:241.04
沸点:
MDL番号:MFCD11846504
保管方法:Store at 2-8°C.

Category Infos

Imidazopyridines
With four imidazopyridine-containing drugs and one pyrazolopyridine-containing drug on the market, bicyclic pyridines containing ring-junction nitrogen are privileged structures in medicinal chemistry. With two nitrogen atoms with potential to serve as hydrogen bond acceptors, imidazopyridines and pyrazolopyridines may boost binding to target proteins and elevate potency. In addition, these structures have found utility in FBDD, covalent inhibitors, reducing metabolic liabilities, and creating novel chemical space and intellectual properties. With many of the advanced intermediates now commercially available, they will find more and more applications in drug discovery.
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Product Other Information

Definition and Background BIPCA is a heterocyclic organic compound that consists of an imidazo[1,5-a]pyridine core and a carboxylic acid functional group at the 1-position. It is a pale yellow solid that is sparingly soluble in water but soluble in organic solvents such as ethanol and acetone. BIPCA was first synthesized in the early 2000s and has since been investigated for its potential use in various applications, including as a building block for the synthesis of biologically active molecules.
Properties ① Physical and Chemical Properties
BIPCA has a molecular formula of C10H6BrN3O2 and a molecular weight of 282.08 g/mol. Its melting point is approximately 240-241°C, and its boiling point is not available in the literature. BIPCA is stable under normal conditions and does not decompose easily. It has a high thermal stability and does not undergo significant degradation when exposed to elevated temperatures. BIPCA is also highly reactive towards nucleophiles due to the presence of the carboxylic acid functional group.

② Biological Properties
BIPCA has been shown to possess biological activity, including antimicrobial, antifungal, and antitumor activity. BIPCA has been studied as a potential anticancer agent due to its ability to inhibit the proliferation of various cancer cell lines, including breast cancer, prostate cancer, and leukemia. BIPCA has also been shown to have antimicrobial activity against various strains of bacteria and fungi.
Synthesis and Characterization BIPCA can be synthesized using various methods, including the reaction of 3-bromo-1H-imidazo[1,5-a]pyridine with potassium cyanate followed by hydrolysis, or by the reaction of 3-bromo-1H-imidazo[1,5-a]pyridine with methyl chloroformate followed by hydrolysis. The resulting product can be purified using column chromatography or recrystallization.
BIPCA can be characterized using various techniques, including nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS), infrared (IR) spectroscopy, and elemental analysis. These techniques can be used to confirm the molecular structure and purity of the product.
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Applications BIPCA has potential applications in various fields of research and industry, including medicinal chemistry, materials science, and chemical synthesis. BIPCA can be used as a building block for the synthesis of biologically active molecules, such as anticancer agents, antibiotics, and antifungals. BIPCA can also be used in the preparation of organic materials, such as polymers and liquid crystals.Contact us to order
Hazard Info Class:14.1.5

H Statements:
H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H332: Harmful if inhaled.
H335: May cause respiratory irritation.

P Statements:
P261: Avoid breathing dust, fumes, gas, mist, vapours, spray. [As modified by IV ATP].
P264: Wash thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing.
P321: Specific treatment (see label).
P330: Rinse mouth.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P337+P313: If eye irritation persists: Get medical advice/attention.
P362+P364: Take off contaminated clothing. [As modified by IV ATP]. And wash it before reuse. [Added by IV ATP].
P403+P233: Store in a well ventilated place. Keep container tightly closed.
P405: Store locked up.

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