cas 1197420-05-5|| where to buy (R)-6-(4-chlorophenyl)-3-(4-(2-cyclopropyl-2-hydroxyethoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one

製品名:(R)-6-(4-chlorophenyl)-3-(4-(2-cyclopropyl-2-hydroxyethoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one

IUPAC Name:6-(4-chlorophenyl)-3-{4-[(2R)-2-cyclopropyl-2-hydroxyethoxy]-3-methoxyphenyl}-3H,4H-thieno[3,2-d]pyrimidin-4-one

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: CAS番号:1197420-05-5; 分子式:C24H21ClN2O4S; 融点:-; SMILESコード:COC1=C(OC[C@H](O)C2CC2)C=CC(=C1)N1C=NC2=C(SC(=C2)C2=CC=C(Cl)C=C2)C1=O; 密度:

: Thienopyrimidines; Thienopyrimidines are a class of heterocyclic compounds with diverse biological activities depending on their detailed substitution patterns. In addition, many thienopyrimidine derivatives have shown potent activity against cancer cell lines and specific oncogenes.

: Cyclopropanes; Cyclopropane is the smallest cyclic compound with unique structural features and physicochemical properties, which is widely used in the design of small molecule drugs. In drug design, it is often used to increase activity, fix conformation and improve PK and water solubility. The introduction of cyclopropyl groups into drugs can change various properties of molecules, such as improving metabolic stability; increasing biological activity; enhancing drug efficacy; limiting polypeptide conformation and slowing down its hydrolysis; reducing plasma clearance; improving drug dissociation and many more. Cyclopropane rings are widely found in marketed drugs, including cardiovascular drugs, central nervous system (CNS) drugs, anticancer drugs, autoimmune and anti-inflammatory drugs.