製品名:2-(Boc-amino)-5-tosyl-5H-pyrrolo[2,3-b]pyrazine

IUPAC Name:tert-butyl N-[5-(4-methylbenzenesulfonyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]carbamate

CAS番号:1201187-44-1
分子式:C18H20N4O4S
純度:95%+
カタログ番号:CM119289
分子量:388.44

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製品詳細

CAS番号:1201187-44-1
分子式:C18H20N4O4S
融点:-
SMILESコード:O=S(N1C=CC2=NC(NC(OC(C)(C)C)=O)=CN=C21)(C3=CC=C(C)C=C3)=O
密度:
カタログ番号:CM119289
分子量:388.44
沸点:
MDL番号:MFCD28129728
保管方法:

Category Infos

Pyrrolopyrazines
Nitrogen-containing heterocyclic compounds have a wide range of applications in medicine, organic materials, natural products and other fields, mainly for biologically active molecules. Pyrrolopyrazines contain pyrrole and pyrazine rings as bioactive scaffolds. Compounds containing this scaffold have a wide range of biological activities, such as antibacterial, anti-inflammatory, antiviral, antifungal, antioxidant, antitumor, and kinase inhibition.

Column Infos

Pyrazines
Pyrazine is a heterocyclic aromatic organic compound with chemical formula C4H4N2. The marketed pyrazine drugs are mainly distributed in the field of anti-tumor and anti-infection. In recent years, there have been many new drugs in various fields, and there are some new target drugs worthy of attention.
Azaindoles
Azaindole can be regarded as the biological isostere of indole, and the molecular unit of indole plays a huge role in the life process. Many drug molecules contain indole units. Azaindole is an important heterocyclic intermediate with good biological and medicinal value, and is the core structure of many drugs, such as antitumor drugs, dopamine D4 receptors, kinase inhibitors, thrombin inhibitors, etc. Therefore, it has a wide range of application value in medical research.
Benzenes
Benzene is an important organic compound with the chemical formula C6H6, and its molecule consists of a ring of 6 carbon atoms, each with 1 hydrogen atom. Benzene is a sweet, flammable, colorless and transparent liquid with carcinogenic toxicity at room temperature, and has a strong aromatic odor. It is insoluble in water, easily soluble in organic solvents, and can also be used as an organic solvent itself. The ring system of benzene is called benzene ring, and the structure after removing one hydrogen atom from the benzene ring is called phenyl. Benzene is one of the most important basic organic chemical raw materials. Many important chemical intermediates can be derived from benzene through substitution reaction, addition reaction and benzene ring cleavage reaction.
Upadacitinib
AbbVie announced positive top-line results from SELECT-GCA, a Phase 3, multicenter, randomized, double-blind, placebo-controlled study, showing upadacitinib (RINVOQ®; 15 mg, once daily) in combination with a 26-week steroid taper regimen achieved its primary endpoint of sustained remission from week 12 through week 52 in adults with giant cell arteritis (GCA). Upadacitinib is a JAK inhibitor that is being studied in several immune-mediated inflammatory diseases.

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