Thiophene is a five-membered heterocyclic compound containing a sulfur heteroatom with the molecular formula C4H4S. Thiophene is aromatic and is very similar to benzene; electrophilic substitution reaction is easier than benzene, and it is mainly substituted at the 2-position. Thiophene ring system has certain stability to oxidant.
Piperidine is an azacycloalkane that is cyclohexane in which one of the carbons is replaced by a nitrogen. Although piperidine is a common organic compound, it is an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.
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Isoxazole is a liquid heterocyclic compound C3H3NO isomeric with oxazole and having a penetrating odor like that of pyridine. Isoxazoles belong to an important class of five-membered aromatic heterocycles containing two electronegative heteroatoms, nitrogen and oxygen, in a 1,2-relationship and three regular sp2 carbon atoms. These molecules are found to be key components in various synthetic products in daily use and also present as a pharmacophore essential for biological activity in many drugs and bioactive natural products. In addition, isoxazoles have demonstrated their ability to exhibit hydrogen bond donor/acceptor interactions with a variety of enzymes and receptors.
Oxazolidines are five-membered ring compounds consisting of three carbons, nitrogen and oxygen. Oxygen and nitrogen are in the 1 and 3 positions, respectively. Oxazolidine is in general yellow or slightly yellow, alkaline liquid or solid, easily hydrolyzed by water or alcohol. It is insoluble in water (or hydrolyzed); soluble in benzene and chloroform. Oxazolidine derivatives are five-membered cyclic compounds containing at least one oxygen and nitrogen in their molecular structure. Oxazolidine derivatives are known to possess various therapeutic activities, such as anticancer and antibiotic properties.
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