cas 1216942-02-7|| where to buy Cyclopropanecarboxylic acid,2-ethenyl-1-[[[(2S,4R)-4-(6-phenanthridinyloxy)-2-pyrrolidinyl]carbonyl]amino]-,ethyl ester,(1R,2S)-

製品名:Cyclopropanecarboxylic acid,2-ethenyl-1-[[[(2S,4R)-4-(6-phenanthridinyloxy)-2-pyrrolidinyl]carbonyl]amino]-,ethyl ester,(1R,2S)-

IUPAC Name:ethyl (1R,2S)-2-ethenyl-1-[(2S,4R)-4-(phenanthridin-6-yloxy)pyrrolidine-2-amido]cyclopropane-1-carboxylate

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: CAS番号:1216942-02-7; 分子式:C26H27N3O4; 融点:-; SMILESコード:CCOC(=O)[C@]1(C[C@H]1C=C)NC(=O)[C@@H]1C[C@H](CN1)OC1=NC2=C(C=CC=C2)C2=C1C=CC=C2; 密度:

: Pyrrolidines; Pyrrolidine, also known as tetrahydropyrrole, is a saturated five-membered heterocyclic ring, which is miscible with water. Pyrrolidine exists in many alkaloids and drug molecules, such as kappa opioids, antagonists of dopamine D4 receptors, and HIV reverse transcriptase inhibitors.

: Cyclopropanes; Cyclopropane is the smallest cyclic compound with unique structural features and physicochemical properties, which is widely used in the design of small molecule drugs. In drug design, it is often used to increase activity, fix conformation and improve PK and water solubility. The introduction of cyclopropyl groups into drugs can change various properties of molecules, such as improving metabolic stability; increasing biological activity; enhancing drug efficacy; limiting polypeptide conformation and slowing down its hydrolysis; reducing plasma clearance; improving drug dissociation and many more. Cyclopropane rings are widely found in marketed drugs, including cardiovascular drugs, central nervous system (CNS) drugs, anticancer drugs, autoimmune and anti-inflammatory drugs.