cas 13861-75-1|| where to buy spiro[cyclopropane-1,3'-indolin]-2'-one

製品名:spiro[cyclopropane-1,3'-indolin]-2'-one

IUPAC Name:1',2'-dihydrospiro[cyclopropane-1,3'-indol]-2'-one

包装単位	有効在庫	価格（USD）
CM138874-1g	in stock	ƱſǕ
CM138874-5g	in stock	ɐƋſ

研究開発用専用.

問い合わせフォーム

化学物質名

CAS番号

数量*

要求仕様*
（アッセイ %、材料グレード等）

お名前*

連絡先Eメールアドレス*

Meanwhile I'd like to create a registered account on CHEMENU.COM with the above email.

I'd like to receive emails related to products with similar structures to 13861-75-1 regularly via the above email.

追記事項

Verification code*

refresh

: CAS番号:13861-75-1; 分子式:C10H9NO; 融点:-; SMILESコード:O=C(C12CC1)NC3=C2C=CC=C3; 密度:

: カタログ番号:CM138874; 分子量:159.19; 沸点:356.8°C at 760 mmHg; MDL番号:MFCD11934419; 保管方法:Store at 2-8°C.

: Cyclopropanes; Cyclopropane is the smallest cyclic compound with unique structural features and physicochemical properties, which is widely used in the design of small molecule drugs. In drug design, it is often used to increase activity, fix conformation and improve PK and water solubility. The introduction of cyclopropyl groups into drugs can change various properties of molecules, such as improving metabolic stability; increasing biological activity; enhancing drug efficacy; limiting polypeptide conformation and slowing down its hydrolysis; reducing plasma clearance; improving drug dissociation and many more. Cyclopropane rings are widely found in marketed drugs, including cardiovascular drugs, central nervous system (CNS) drugs, anticancer drugs, autoimmune and anti-inflammatory drugs.

: Spiro Compounds; A spiro compound is a polycyclic compound in which two monocyclic rings share one carbon atom; the shared carbon atom is called a spiro atom. Spiro compounds have rigid structures, stable structures, and have special properties that general organic compounds do not possess, such as anomeric effect, spiro conjugation and spiro hyperconjugation. Compared with the monocyclic structure or the planar aromatic structure, the spiro structure has a larger three-dimensional structure; the heterocyclic spiro structure is also regarded as the biological isostere of some groups, which can change the drug to a certain extent. The water solubility, lipophilicity, dominant conformation and ADMET properties of the molecule make the optimized lead molecule easier to drug. Therefore, spiro compounds occupy a very important position in drug development.