cas 1440965-10-5|| where to buy 3-chloro-6-(1-cyclopropyl-1H-pyrazol-4-yl)pyridazine

製品名:3-chloro-6-(1-cyclopropyl-1H-pyrazol-4-yl)pyridazine

IUPAC Name:3-chloro-6-(1-cyclopropyl-1H-pyrazol-4-yl)pyridazine

: CAS番号：1440965-10-5; 分子式：C10H9ClN4; 純度：95%+

: カタログ番号：CM329443; 分子量：220.66

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CM329443-100mg	in stock	ƻț
CM329443-250mg	in stock	țƀȁ
CM329443-1g	in stock	ȁƀƙ

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製品詳細

: CAS番号:1440965-10-5; 分子式:C10H9ClN4; 融点:-; SMILESコード:ClC1=NN=C(C2=CN(C3CC3)N=C2)C=C1; 密度:

: カタログ番号:CM329443; 分子量:220.66; 沸点:; MDL番号:; 保管方法:-20°C

Category Infos

: Pyridazines; Pyridazine, also known as o-diazobenzene, is a six-membered heterocyclic compound containing two nitrogen heteroatoms in the 1 and 2 positions with a special structure and a wide biological activity. Pyridazine is more and more popular in drug development, and a variety of pyridazine drugs have been developed and marketed. From the perspective of the therapeutic field, pyridazine drug molecules are mainly used for tumor treatment, but also involve in many therapeutic fields such as inflammation, hypertension and cardiovascular disease. With the increase and in-depth of research, pyridazine drugs will play more roles in the treatment of diseases.

: Pyrazoles; Pyrazoles are organic compounds of the general formula C3H3N2H. It is a five-membered heterocycle consisting of three carbon atoms and two adjacent nitrogen atoms. As an H-bond-donating heterocycle, pyrazole has been used as a more lipophilic and metabolically more stable bioisomer of phenol. Pyrazoles have attracted more and more attention due to their broad spectrum of action and strong efficacy.; Pyrazone; Custom pyrazone for customers from all over the world are our main business.

: Cyclopropanes; Cyclopropane is the smallest cyclic compound with unique structural features and physicochemical properties, which is widely used in the design of small molecule drugs. In drug design, it is often used to increase activity, fix conformation and improve PK and water solubility. The introduction of cyclopropyl groups into drugs can change various properties of molecules, such as improving metabolic stability; increasing biological activity; enhancing drug efficacy; limiting polypeptide conformation and slowing down its hydrolysis; reducing plasma clearance; improving drug dissociation and many more. Cyclopropane rings are widely found in marketed drugs, including cardiovascular drugs, central nervous system (CNS) drugs, anticancer drugs, autoimmune and anti-inflammatory drugs.

Column Infos

: Vebreltinib; Avistone announced that they received conditional approval from the National Medical Products Administration (NMPA) to commercialize Vebreltinib (Bozitinib) to treat patients with MET exon 14 skipping non-small cell lung cancer (NSCLC) in China. The conditional approval was based on results from a pivotal Phase II KUNPENG study with an objective response rate (ORR) of 75.0% and median progression-free survival (PFS) in patients with advanced METex14 mutations to 14.1 months with a good safety profile as was recently presented at the 2023 European Society for Clinical Oncology (ESMO) Congress in Madrid, Spain. Vebreltinib is a potent, small molecule, orally bioavailable and highly selective c-Met Tyrosine Kinase Inhibitor (TKI).
Chemenu has been working to develop more compounds for drug discovery. Here are the building blocks we can provide.

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