製品名:tert-butyl N-(4-methylpiperidin-4-yl)carbamate

IUPAC Name:tert-butyl N-(4-methylpiperidin-4-yl)carbamate

CAS番号:163271-08-7
分子式:C11H22N2O2
純度:95%+
カタログ番号:CM103826
分子量:214.31

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製品詳細

CAS番号:163271-08-7
分子式:C11H22N2O2
融点:-
SMILESコード:CC(C)(C)OC(=O)NC1(C)CCNCC1
密度:
カタログ番号:CM103826
分子量:214.31
沸点:308°C at 760 mmHg
MDL番号:MFCD08703167
保管方法:Store at 2-8°C.

Category Infos

Piperidines
Piperidine is an azacycloalkane that is cyclohexane in which one of the carbons is replaced by a nitrogen. Although piperidine is a common organic compound, it is an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.
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Column Infos

Darovasertib
The Journal of Medicinal Chemistry recently publishes an article titled, “Discovery of Darovasertib, a Pan-PKC Inhibitor for the Treatment of Metastatic Uveal Melanoma”. Uveal melanoma (UM) is the most common primary intraocular malignancy. About half of primary uveal melanoma tumors metastasize but with no standard treatment. Most patients with metastatic uveal melanoma have been found to have mutations in GNAQ or GNA11, that are associated with consistent activation of the protein kinase C (PKC) and mitogen-activated protein kinase (MAPK) pathways.
IDEAYA's Darovasertib (IDE196) is a potent, selective small molecule inhibitor of PKC which stops activating PKC/MEK pathway. Darovasertib is under Phase 2 expansion and Phase 3 registrational trial with Crizotinib in GNAQ/11 metastatic cutaneous melanoma.

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