Pyrimidine, also known as 1,3-diazobenzene, is a heterocyclic compound with the chemical formula C4H4N2. Pyrimidine is formed by substituting 2 nitrogen atoms for 2 carbons in the meta-position of benzene. It is a diazine and retains its aromaticity. Derivatives of pyrimidine widely exist in organic macromolecular nucleic acids, and many drugs also contain pyrimidine rings. In nucleic acids, three nucleobases are pyrimidine derivatives: cytosine, thymine and uracil. There are a variety of pyrimidine-containing drugs on the market, most of which are kinase inhibitors.
The novel medication for the treatment of adults with major depressive disorder (MDD), Gepirone has eventually been approved by the FDA in late September following a long quest. Geprione belongs to the azapirone group, as the same class as buspirone. Gepirone acts as a full agonist at serotonin 5-HT1A autoreceptors and is generally, a partial agonist at postsynaptic serotonin 5-HT1A receptors. Gepirone has a unique antidepressant effect that relieves depressive symptoms without significant side effects.
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