製品名:6-Chloro-2,8-dimethylimidazo[1,2-b]pyridazine

IUPAC Name:6-chloro-2,8-dimethylimidazo[1,2-b]pyridazine

CAS番号:17412-23-6
分子式:C8H8ClN3
純度:95%+
カタログ番号:CM330120
分子量:181.62

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CM330120-50mg in stock ŮŮ
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CM330120-250mg in stock ǟħƴ
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CM330120-5g in stock ŌǸǸ

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製品詳細

CAS番号:17412-23-6
分子式:C8H8ClN3
融点:-
SMILESコード:CC1=CC(Cl)=NN2C1=NC(C)=C2
密度:
カタログ番号:CM330120
分子量:181.62
沸点:
MDL番号:MFCD27946129
保管方法:

Category Infos

Imidazopyridazines
Potent IRAK-4 inhibitors have been reported by several groups including some structurally related benzimidazoles as well as alternative fused heterocycles such as the imidazopyridine and imidazopyridazine. Such compounds are reported to have IRAK-1 and IRAK-4 activity with varying degrees of selectivity.

Column Infos

Risdiplam
As the first approved small molecule splicing modifier drug, Risdiplam (Evrysdi) is granted approval by the European Commission to expand the EU marketing authorization. This extension now includes infants with a clinical diagnosis of SMA Type 1, Type 2 or Type 3 or with one to four SMN2 copies from birth to below two months. Type 1 spinal muscular atrophy (SMA) is a rare, progressive neuromuscular disease and a leading genetic factor of infant mortality, that is caused by low levels of functional survival of motor neuron (SMN) protein. Risdiplam modifies SMN2 pre-messenger RNA splicing and increases levels of functional SMN protein in both the central nervous system and peripheral organs.