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  2. Category: ADC-Linkers、Cleavable linkers、PEG linkers、Biotin、Azides
  3. product Cas No.: 2055198-04-2

製品名:PC-Biotin-PEG4-PEG3-azide

IUPAC Name:1-{5-[(1-{5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamido}-3,6,9,12-tetraoxapentadecan-15-amido)methyl]-2-nitrophenyl}ethyl N-(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethyl)carbamate

CAS番号：2055198-04-2
分子式：C39H63N9O14S
純度：95%+
カタログ番号：CM338993
分子量：914.04
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製品詳細

CAS番号:2055198-04-2
分子式:C39H63N9O14S
融点:-
SMILESコード:O=C(OC(C1=CC(CNC(CCOCCOCCOCCOCCNC(CCCC[C@@H]2SC[C@]([C@]2([H])N3)([H])NC3=O)=O)=O)=CC=C1[N+]([O-])=O)C)NCCOCCOCCOCCN=[N+]=[N-]
密度:
カタログ番号:CM338993
分子量:914.04
沸点:
MDL番号:
保管方法:

Category Infos

ADC-Linkers
The ADC linker is one of the three main components of antibody drug conjugates (ADCs), linking the antibody to the effective drug (payload) through chemical bonds. ADC linkers play a key role in determining the overall success of antibody drug conjugates. One of the major challenges in developing safe and effective ADC drugs is to assemble an ideal chemical linker between the cytotoxic payload and the mAb. Well-designed ADC linkers can help the selective delivery of antibodies at the tumor site and the accurate release of cytotoxic drugs.
Cleavable linkers
Cleavable linkers rely on the inherent properties of a cell’s cytoplasmic compartments for selective release of the cytotoxic drug.
PEG linkers
PEG Reagents are chemically functionalized polyethylene glycol (PEG) linkers.PEG linkers are highly water-soluble and non-immunogenic linkers.
Biotin
Biotin is necessary for formation of fatty acids and glucose, which are used as fuels by the body.
Azides
Azides are used in click chemistry, such as copper-catalyzed azide-alkyne [3+2] cycloaddition (CuAAC),and strain-promoted [3+2] azide-alkyne cycloaddition reaction (SPAAC).