Pyrazoles are organic compounds of the general formula C3H3N2H. It is a five-membered heterocycle consisting of three carbon atoms and two adjacent nitrogen atoms. As an H-bond-donating heterocycle, pyrazole has been used as a more lipophilic and metabolically more stable bioisomer of phenol. Pyrazoles have attracted more and more attention due to their broad spectrum of action and strong efficacy.
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Quinoxalines, also known as benzopyrazines, are heterocyclic compounds containing a ring complex consisting of a benzene ring and a pyrazine ring. It has isomerism with other naphthalene compounds such as quinazoline, phthalazine, cinnamine, etc. Fusion N-heterocyclic compounds are widely used as valuable entities for the expansion of important pharmacological agents and are considered to be an advantageous scaffold material. Among the numerous fused N-heterocyclic compounds, cinnoline, quinoxaline and quinazoline are important pharmacological agents. In medicinal chemistry, these N-heterocyclic compounds have a wide range of biological properties and can be used as synthetic intermediates, potential drug candidates and chemical probes.
Pyrrolidine, also known as tetrahydropyrrole, is a saturated five-membered heterocyclic ring, which is miscible with water. Pyrrolidine exists in many alkaloids and drug molecules, such as kappa opioids, antagonists of dopamine D4 receptors, and HIV reverse transcriptase inhibitors.
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