製品名:benzenesulfonic acid;(3S)-3-(3-oxo-6-piperazin-1-yl-1H-isoindol-2-yl)piperidine-2,6-dione

IUPAC Name:(3S)-3-[1-oxo-5-(piperazin-1-yl)-2,3-dihydro-1H-isoindol-2-yl]piperidine-2,6-dione; benzenesulfonic acid

CAS番号:2229714-16-1
分子式:C23H26N4O6S
純度:98%
カタログ番号:CM545826
分子量:486.54

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製品詳細

CAS番号:2229714-16-1
分子式:C23H26N4O6S
融点:-
SMILESコード:OS(=O)(=O)C1=CC=CC=C1.O=C1N(CC2=C1C=CC(=C2)N1CCNCC1)[C@H]1CCC(=O)NC1=O
密度:
カタログ番号:CM545826
分子量:486.54
沸点:
MDL番号:
保管方法:

Category Infos

Piperidines
Piperidine is an azacycloalkane that is cyclohexane in which one of the carbons is replaced by a nitrogen. Although piperidine is a common organic compound, it is an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.
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Piperazines
Piperazine is an organic compound consisting of a six-membered ring containing two nitrogen atoms in opposite positions in the ring. The chemical formula of piperazine is C4H10N2, and it is an important pharmaceutical intermediate. Pyrimidines and piperazines are known to be the backbone of many bulk compounds and important core structures for approved drugs; studies have shown that combining a pyridine ring with a piperazine moiety within a single structural framework enhances biological activity.

Column Infos

Vepdegestrant
Arvinas and Pfizer updated clinical data from a Phase 1b combination cohort evaluating vepdegestrant in combination with palbociclib. These data show that vepdegestrant plus palbociclib continue to demonstrate encouraging clinical activity in heavily pre-treated patients with a median of four lines of prior therapy with locally advanced or metastatic ER positive/human epidermal growth factor 2 – HER2 – negative breast cancer. Vepdegestrant is an investigational PROTAC ER degrader designed to harness the body’s natural protein disposal system to specifically target and degrade the estrogen receptor.