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  2. Category: ADC-Linkers、Cleavable linkers、Peptide linkers、PEG linkers、Alkynes
  3. product Cas No.: 2253947-17-8

製品名:DBCO-PEG3 acetic-EVCit-PAB

IUPAC Name:tert-butyl (4S)-4-[2-(2-{2-[2-(4-{2-azatricyclo[10.4.0.0⁴,⁹]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl}-4-oxobutanamido)ethoxy]ethoxy}ethoxy)acetamido]-4-{[(1S)-1-{[(1S)-4-(carbamoylamino)-1-{[4-(hydroxymethyl)phenyl]carbamoyl}butyl]carbamoyl}-2-methylp

CAS番号：2253947-17-8
分子式：C54H72N8O13
純度：95%+
カタログ番号：CM339029
分子量：1041.21
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製品詳細

CAS番号:2253947-17-8
分子式:C54H72N8O13
融点:-
SMILESコード:O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCC(NCCOCCOCCOCC(N[C@@H](CCC(OC(C)(C)C)=O)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC4=CC=C(CO)C=C4)=O)=O)=O)=O)=O
密度:
カタログ番号:CM339029
分子量:1041.21
沸点:
MDL番号:
保管方法:

Category Infos

ADC-Linkers
The ADC linker is one of the three main components of antibody drug conjugates (ADCs), linking the antibody to the effective drug (payload) through chemical bonds. ADC linkers play a key role in determining the overall success of antibody drug conjugates. One of the major challenges in developing safe and effective ADC drugs is to assemble an ideal chemical linker between the cytotoxic payload and the mAb. Well-designed ADC linkers can help the selective delivery of antibodies at the tumor site and the accurate release of cytotoxic drugs.
Cleavable linkers
Cleavable linkers rely on the inherent properties of a cell’s cytoplasmic compartments for selective release of the cytotoxic drug.
Peptide linkers
Peptide linkers belong to protease-sensitivity linkers (also called enzymatically cleavable linkers) that have gained significant attention in ADC development due to their superior plasma stability and controled payload release mechanism.
PEG linkers
PEG Reagents are chemically functionalized polyethylene glycol (PEG) linkers.PEG linkers are highly water-soluble and non-immunogenic linkers.
Alkynes
Alkynes are unsaturated hydrocarbons containing at least one carbon—carbon triple bond.