製品名:3-aminopiperidine-2,6-dione

IUPAC Name:3-aminopiperidine-2,6-dione

CAS番号:2353-44-8
分子式:C5H8N2O2
純度:95%
カタログ番号:CM132080
分子量:128.13

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製品詳細

CAS番号:2353-44-8
分子式:C5H8N2O2
融点:-
SMILESコード:NC1CCC(=O)NC1=O
密度:
カタログ番号:CM132080
分子量:128.13
沸点:334.5°C at 760 mmHg
MDL番号:MFCD11506223
保管方法:Keep in dark place, store at 2-8°C.

Category Infos

Piperidines
Piperidine is an azacycloalkane that is cyclohexane in which one of the carbons is replaced by a nitrogen. Although piperidine is a common organic compound, it is an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.
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Column Infos

NX-2127
Existing BTK inhibitors directly bind to the active site of BTK and face challenges such as acquired resistance or incomplete responses over time. PROTAC-induced BTK degradation works as a novel alternative therapy for drug-resistant cancers. The latest journal Science publishes the identification of BTK mutations that are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127.
Nurix Therapeutics’ TPD compound NX-2127 is a first-in-class, dual-function small-molecule protein degrader. It drives targeted BTK and transcription factor IKAROS (IKZF1/3) degradation through ubiquitination and proteasomal degradation, adding combined benefit. NX-2127 is under development of phase I clinical trials that shows promising results and a manageable safety profile for the treatment of relapsed/ refractory B-cell malignancies.