cas 2375021-29-5|| where to buy N-[(1S)-1-{3-[3-amino-4-chloro-1-(2,2,2-trifluoroethyl)-1H-indazol-7-yl]-6-(3-methanesulfonyl-3-methylbut-1-yn-1-yl)pyridin-2-yl}-2-(3,5-difluorophenyl)ethyl]-2-[(2S,4R)-5,5-difluoro-9-(trifluoromethyl)-7,8-diazatricyclo[4.3.0.0²,⁴]nona-1(6),8-dien-7-yl]a

製品名:N-[(1S)-1-{3-[3-amino-4-chloro-1-(2,2,2-trifluoroethyl)-1H-indazol-7-yl]-6-(3-methanesulfonyl-3-methylbut-1-yn-1-yl)pyridin-2-yl}-2-(3,5-difluorophenyl)ethyl]-2-[(2S,4R)-5,5-difluoro-9-(trifluoromethyl)-7,8-diazatricyclo[4.3.0.0²,⁴]nona-1(6),8-dien-7-yl]a

IUPAC Name:N-[(1S)-1-{3-[3-amino-4-chloro-1-(2,2,2-trifluoroethyl)-1H-indazol-7-yl]-6-(3-methanesulfonyl-3-methylbut-1-yn-1-yl)pyridin-2-yl}-2-(3,5-difluorophenyl)ethyl]-2-[(2S,4R)-5,5-difluoro-9-(trifluoromethyl)-7,8-diazatricyclo[4.3.0.0²,⁴]nona-1(6),8-dien-7-yl]acetamide; methanesulfonic acid; propan-1-ol

: CAS番号：2375021-29-5; 分子式：C42H42ClF10N7O7S2; 純度：95%+

: カタログ番号：CM1079190; 分子量：1046.39

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製品詳細

: CAS番号:2375021-29-5; 分子式:C42H42ClF10N7O7S2; 融点:-; SMILESコード:C(CO)C.S(C)(=O)(=O)O.C(F)(F)(F)C=1C=2[C@@]3([C@@](C3)(C(F)(F)C2N(CC(N[C@@H](CC4=CC(F)=CC(F)=C4)C5=C(C=CC(C#CC(S(C)(=O)=O)(C)C)=N5)C6=C7C(C(N)=NN7CC(F)(F)F)=C(Cl)C=C6)=O)N1)[H])[H]; 密度:

: カタログ番号:CM1079190; 分子量:1046.39; 沸点:; MDL番号:; 保管方法:

Category Infos

: Cyclopropanes; Cyclopropane is the smallest cyclic compound with unique structural features and physicochemical properties, which is widely used in the design of small molecule drugs. In drug design, it is often used to increase activity, fix conformation and improve PK and water solubility. The introduction of cyclopropyl groups into drugs can change various properties of molecules, such as improving metabolic stability; increasing biological activity; enhancing drug efficacy; limiting polypeptide conformation and slowing down its hydrolysis; reducing plasma clearance; improving drug dissociation and many more. Cyclopropane rings are widely found in marketed drugs, including cardiovascular drugs, central nervous system (CNS) drugs, anticancer drugs, autoimmune and anti-inflammatory drugs.