製品名:Dexamethasone 9,11-epoxide

IUPAC Name:(1S,2S,10S,11S,13R,14R,15S,17S)-14-hydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyl-18-oxapentacyclo[8.8.0.0¹,¹⁷.0²,⁷.0¹¹,¹⁵]octadeca-3,6-dien-5-one

CAS番号:24916-90-3
分子式:C22H28O5
純度:98%
カタログ番号:CM397973
分子量:372.46

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製品詳細

CAS番号:24916-90-3
分子式:C22H28O5
融点:-
SMILESコード:C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]33O[C@H]3C[C@]2(C)[C@@]1(O)C(=O)CO
密度:
カタログ番号:CM397973
分子量:372.46
沸点:
MDL番号:
保管方法:

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Steroids
Naturally occurring steroids are estrogen, cortisol, progesterone, and testosterone. Pharmacologically, they are used in several ways: alter steroid metabolism via statins to help lower cholesterol; as corticosteroids to help control inflammation, asthma, and lupus; and other forms to help hormone deficiency, such as delayed puberty, as well as diseases that result in loss of lean muscle mass, such as cancer and AIDS.
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Vamorolone
Dec 18, 2023, AGAMREE (vamorolone) has been approved in the European Union (EU) for the treatment of DMD in patients 4 years of age and older.
Duchenne muscular dystrophy (DMD) is a genetic muscle disease. And The feature is contraction-induced myofibre injury and inflammation. Researchers found that NF-κB signaling is active in dystrophin deficient muscle. Therefore, Inhibiting NF-κB is a potent strategy for the treatment of DMD. Vamorolone is an investigational drug that was developed as a novel dissociative steroidal anti-inflammatory. This means that its chemical profile is such that it shows chemical separation of efficacy (clinical benefit) from some safety concerns (side effect profiles) typically seen with corticosteroids. 
AGAMREE is the only approved medication in the EU for treating DMD, and the first DMD treatment approved in both the U.S. and EU.

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