cas 27192-21-8|| where to buy 5-Bromo-4-chloro-6-cyclopropylpyrimidine

製品名:5-Bromo-4-chloro-6-cyclopropylpyrimidine

IUPAC Name:5-bromo-4-chloro-6-cyclopropylpyrimidine

: CAS番号：27192-21-8; 分子式：C7H6BrClN2; 純度：95%+

: カタログ番号：CM1051304; 分子量：233.49

包装単位	有効在庫	価格（USD）
CM1051304-100mg	in stock	ňź
CM1051304-250mg	in stock	źȀź

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製品詳細

: CAS番号:27192-21-8; 分子式:C7H6BrClN2; 融点:-; SMILESコード:ClC1=C(Br)C(=NC=N1)C1CC1; 密度:

: カタログ番号:CM1051304; 分子量:233.49; 沸点:; MDL番号:MFCD11047047; 保管方法:

Category Infos

: Cyclopropanes; Cyclopropane is the smallest cyclic compound with unique structural features and physicochemical properties, which is widely used in the design of small molecule drugs. In drug design, it is often used to increase activity, fix conformation and improve PK and water solubility. The introduction of cyclopropyl groups into drugs can change various properties of molecules, such as improving metabolic stability; increasing biological activity; enhancing drug efficacy; limiting polypeptide conformation and slowing down its hydrolysis; reducing plasma clearance; improving drug dissociation and many more. Cyclopropane rings are widely found in marketed drugs, including cardiovascular drugs, central nervous system (CNS) drugs, anticancer drugs, autoimmune and anti-inflammatory drugs.

Column Infos

: TNG348; Dose escalation is ongoing in the TNG348, a novel inhibitor of USP1 (ubiquitin-specific protease 1), phase 1/2 clinical trial evaluating the safety, pharmacokinetics, pharmacodynamics and efficacy of TNG348 as a single agent and in combination with olaparib, a PARP inhibitor, in patients with BRCA1/2 mutant and other HRD+ (homologous recombination deficient) cancers. The first patient dosed was announced in January 2024.Chemenu has been working to develop more compounds for drug discovery. Here are the building blocks we can provide.

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