cas 2763157-90-8|| where to buy 5,7-dichloro-8-fluoro-2-(methylsulfanyl)-3H,4H-pyrido[4,3-d]pyrimidin-4-one

製品名:5,7-dichloro-8-fluoro-2-(methylsulfanyl)-3H,4H-pyrido[4,3-d]pyrimidin-4-one

IUPAC Name:5,7-dichloro-8-fluoro-2-(methylsulfanyl)-3H,4H-pyrido[4,3-d]pyrimidin-4-one

: CAS番号：2763157-90-8; 分子式：C8H4Cl2FN3OS; 純度：95%+

: カタログ番号：CM1043992; 分子量：280.1

包装単位	有効在庫	価格（USD）
CM1043992-100mg	in stock	Ȭțȁ
CM1043992-250mg	in stock	Ȭǧƻ
CM1043992-1g	in stock	ȁŴƀ
CM1043992-5g	in stock	Ȭțƀƀ

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製品詳細

: CAS番号:2763157-90-8; 分子式:C8H4Cl2FN3OS; 融点:-; SMILESコード:CSC1=NC2=C(C(=O)N1)C(=NC(=C2F)Cl)Cl; 密度:

: カタログ番号:CM1043992; 分子量:280.1; 沸点:; MDL番号:; 保管方法:

Category Infos

: Pyridopyrimidines

Column Infos

: HRS-4642; HRS-4642 is a high affinity, selective, long-acting, and non-covalent KRAS G12D inhibitor, with an affinity constant of 0.083 nM. HRS-4642 demonstrated robust efficacy against KRAS G12D-mutant cancers both in vitro and in vivo. Importantly, in a phase 1 clinical trial, HRS-4642 exhibited promising anti-tumor activity in the escalating dosing cohorts. Furthermore, the sensitization and resistance spectrum for HRS-4642 was deciphered through genome-wide CRISPR-Cas9 screening, which unveiled proteasome as a sensitization target. HRS-4642, either as a single agent or in combination with carfilzomib, reshaped the tumor microenvironment toward an immune-permissive one.

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