cas 2803882-16-6|| where to buy 3-[6-(hydroxymethyl)-1-oxo-2,3-dihydro-1H-isoindol-2-yl]piperidine-2,6-dione

製品名:3-[6-(hydroxymethyl)-1-oxo-2,3-dihydro-1H-isoindol-2-yl]piperidine-2,6-dione

IUPAC Name:3-[6-(hydroxymethyl)-1-oxo-2,3-dihydro-1H-isoindol-2-yl]piperidine-2,6-dione

: CAS番号：2803882-16-6; 分子式：C14H14N2O4; 純度：95%+

: カタログ番号：CM1044949; 分子量：274.28

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CM1044949-50mg	in stock	ȷȷǲƼ
CM1044949-100mg	in stock	ȷɐƤȌ
CM1044949-500mg	in stock	ȌƋƼƤ

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製品詳細

: CAS番号:2803882-16-6; 分子式:C14H14N2O4; 融点:-; SMILESコード:OCC1=CC=C2CN(C3CCC(=O)NC3=O)C(=O)C2=C1; 密度:

: カタログ番号:CM1044949; 分子量:274.28; 沸点:; MDL番号:; 保管方法:

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: Isoindolines

Column Infos

: MRT-2359; Aberrant MYC pathway activation is found in cancer cells, while MYC-induced protein translation depends on GSPT1. Molecular glues targeting GSPT1 is identified as a potential treatment method in oncology. Monte Rosa’s MRT-2359 is an oral and selective molecular glue degrader of the translation termination factor GSPT1. The targeted GSPT1 degradation results in disrupting MYC-driven protein translation and reducing MYC-oncogenic signaling.
MRT-2359 is in an ongoing phase 1/2 study in MYC-driven solid tumors with a current assessment of 0.75 mg dose level. The final phase 2 dose determination and updated clinical results are anticipated in the second half of 2024. MRT-2359 previously received Fast Track Designation in patients with previously treated, metastatic NSCLC with L-MYC or N-MYC expression, Orphan Drug Designation in small cell lung cancer (SCLC), and Fast Track Designation in previously treated, metastatic SCLC with L-MYC or N-MYC expression.

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