Pyrrolidine, also known as tetrahydropyrrole, is a saturated five-membered heterocyclic ring, which is miscible with water. Pyrrolidine exists in many alkaloids and drug molecules, such as kappa opioids, antagonists of dopamine D4 receptors, and HIV reverse transcriptase inhibitors.
Carbazoles are an important class of nitrogen-containing heterocycles with a planar tricyclic skeleton consisting of two benzene rings fused on both sides of the central pyrrole ring, with a large aromatic system and a central nitrogen atom, showing broad of electron delocalization. The structure of this compound is based on the indole structure, but in which a second benzene ring is fused to a five-membered ring at positions 2-3 of the indole. Carbazole structural motifs are widely found in, but not limited to, a large number of natural alkaloids of plant or bacterial origin. Since many of these alkaloids are medically useful, exhibit a fairly wide range of biological activities (anticancer, anti-HIV, antibacterial, anti-Alzheimer's disease, anticoagulant, analgesic, antiepileptic, antidiabetic, antioxidant, etc.). Medicinal chemistry also uses carbazole motifs in synthetic drugs to combat hypertension, heart disease, and hepatitis C virus replication.
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Benzotriazole is a bicyclic nitrogen heterocycle formed by the fusion of the benzene ring with the 4,5-positions or the “d” site of 1H-1,2,3-triazole. The benzotriazoles are known as important intermediates in the preparation of organic products such as β-amido ketones, aldehydes, β-ketoesters, ionic liquid, and as reagents for acylation and thioacylation reactions. 1H-Benzotriazoles are also known to exhibit broad spectrum of pharmacological activities. There are numerous benzotriazole-based clinically used drugs in the market for the treatment of various diseases.
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