Piperidine is an azacycloalkane that is cyclohexane in which one of the carbons is replaced by a nitrogen. Although piperidine is a common organic compound, it is an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.
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Tetrahydroisoquinoline is an organic compound with the chemical formula C9H11N. It is classified as a secondary amine, obtained from isoquinoline by hydrogenation. The tetrahydroisoquinoline moiety forms the backbone of several natural, synthetic and semi-synthetic drugs approved for the treatment of cancer, pain, gout and various neurodegenerative diseases.
Neurocrine Biosciences announced interim results from the ongoing open-label KINECT®-HD2 study about INGREZZA® (Valbenazine) capsules when used for the long-term treatment of adults with chorea associated with Huntington's disease (HD). Interim data suggest one-capsule, once-daily INGREZZA improved chorea at the first evaluation at Week 2 with sustained efficacy through Week 50. INGREZZA® (Valbenazine) is the only one-capsule, once-daily selective vesicular monoamine transporter 2 (VMAT2) inhibitor approved by FDA for the treatment of adults with tardive dyskinesia and the treatment of chorea associated with Huntington's disease (HD). Chemenu has been working to develop more compounds for drug discovery. Here are the building blocks we can provide.
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