cas 42754-96-1|| where to buy 4,6-dichloro-1H-pyrazolo[3,4-d]pyrimidine

製品名:4,6-dichloro-1H-pyrazolo[3,4-d]pyrimidine

IUPAC Name:4,6-dichloro-1H-pyrazolo[3,4-d]pyrimidine

包装単位	有効在庫	価格（USD）
CM104106-5g	in stock	ƿľ
CM104106-25g	in stock	ǙŤŤ
CM104106-100g	in stock	ȃǙŤ

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: CAS番号:42754-96-1; 分子式:C5H2Cl2N4; 融点:-; SMILESコード:ClC1=NC(Cl)=C2C=NNC2=N1; 密度:

: カタログ番号:CM104106; 分子量:189; 沸点:; MDL番号:MFCD09835493; 保管方法:Keep in inert atmosphere, store at 2-8°C.

: Pyrazolopyrimidines; Pyrazolopyrimidine scaffolds are one of the most important heterocyclic compounds in drug discovery. This scaffold has various biological activities, among which anticancer is an important one.

: ORIC-533; ORIC-533 is a potential best-in-class, oral inhibitor of CD73 developed by ORIC Pharmaceuticals which is currently in a Ph. Ib trial for the treatment of relapsed/refractory multiple myeloma (MM). It inhibits the CD73-mediated conversion of AMP to adenosine which generates an immunosuppressive tumor microenvironment and has the potential to be a next-generation immunotherapy. The in-depth use of co-crystal structures led the team to discover a novel set of phosphonate bioisosteres which were able to achieve bioavailability for a highly polar scaffold. The structure and discovery story of ORIC-533 were recently presented at the ACS Spring 2024 Meeting in New Orleans.
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