製品名:4-Chloro-8-methoxy-2-methylquinoline

IUPAC Name:4-chloro-8-methoxy-2-methylquinoline

CAS番号:64951-58-2
分子式:C11H10ClNO
純度:95%+
カタログ番号:CM146319
分子量:207.66

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CM146319-25g in stock ƦNJȬ

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製品詳細

CAS番号:64951-58-2
分子式:C11H10ClNO
融点:-
SMILESコード:COC1=CC=CC2=C1N=C(C)C=C2Cl
密度:
カタログ番号:CM146319
分子量:207.66
沸点:308.8°C at 760 mmHg
MDL番号:MFCD00272401
保管方法:Store at 2-8°C.

Category Infos

Quinolines
Quinolines are an important class of biologically active heterocyclic compounds, and their derivatives usually exhibit a variety of biological activities. They can be used as antimalarial drugs and in the preparation of other antimalarial drugs. Other important activities of quinoline derivatives include inhibitory activity against EGFR-TK and antipsychotic activity. Futhermore, quinoline scaffolds are present in various drug molecules, including the antimalarial drugs aablaquine, chloroquine, mefloquine and primaquine, and the antibacterial agents gatifloxacin, levofloxacin, and moxifloxacin.
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Column Infos

Deucrictibant
Pharvaris announced positive top-line data from the CHAPTER-1 Phase 2 clinical study meeting its primary endpoint, with deucrictibant demonstrating statistically significant and clinically meaningful results of deucrictibant as an oral preventative treatment for people living with HAE. The study's primary endpoint measured the time-standardized number of investigator-confirmed HAE episodes during treatment. Participants receiving 40 mg of deucrictibant daily had an 84.5% reduction in monthly exacerbation rates compared to placebo (p=0.0008). Deucrictibant is a potent, selective, and orally available antagonist of the bradykinin B2 receptor. By inhibiting bradykinin signaling through the bradykinin B2 receptor, deucrictibant has the potential to treat the clinical signs of an HAE attack and to prevent the occurrence of attacks.
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