製品名:3,3-bis(chloromethyl)oxetane

IUPAC Name:3,3-bis(chloromethyl)oxetane

CAS番号:78-71-7
分子式:C5H8Cl2O
純度:95%+
カタログ番号:CM104051
分子量:155.02

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製品詳細

CAS番号:78-71-7
分子式:C5H8Cl2O
融点:-
SMILESコード:ClCC1(CCl)COC1
密度:
カタログ番号:CM104051
分子量:155.02
沸点:
MDL番号:MFCD00027377
保管方法:Keep in inert atmosphere, store at 2-8°C.

Category Infos

Oxetanes
Oxygen heterocycles are one of the most common heterocycles in drugs and natural products. Oxetene has high polarity and is also a good acceptor for hydrogen bond, which contributes to the metabolism and chemical stability of its host molecules. When substituted for commonly used functional groups such as gem dimethyl or carbonyl, oxetane units can induce profound changes in water solubility, lipophilicity, metabolic stability and conformational preference. Four of the FDA-approved drugs contain oxetenes: Orlistat, Paclitaxel, and two of its derivatives, Docetaxel and Cabazitaxel. Currently, oxetane-containing building blocks are flourishing in medicinal chemistry and drug discovery.

Column Infos

Alicyclic Heterocycles
When the ends of the chains are joined together into a ring, cyclic compounds result; such substances often are referred to as carbocyclic or alicyclic compounds. Substitution of one or more of the ring carbon atoms in the molecules of a carbocyclic compound with a heteroatom gives a heterocyclic compound.