製品名:3-(3H-diazirin-3-yl)phenol
IUPAC Name:3-(3H-diazirin-3-yl)phenol
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| Product Overview |
3-Hydroxyphenyl-3H-diazirine (HPD) is a diazirine-containing compound that has been used extensively in scientific research. |
| Synthesis Method |
3-Hydroxyphenyl-3H-diazirine can be synthesized by the reaction of 3-hydroxybenzaldehyde with hydrazine hydrate, followed by treatment with triethyl orthoformate and trifluoroacetic acid. This method results in a high yield of pure 3-Hydroxyphenyl-3H-diazirine, which can be used for various research applications. |
| Chemical Properties |
3-Hydroxyphenyl-3H-diazirine is relatively easy to synthesize and can be used in a wide range of experimental systems. |
| Synthesis and Application |
3-Hydroxyphenyl-3H-diazirine has been widely used in scientific research due to its ability to covalently modify biomolecules upon exposure to UV light. It has been used to study protein-protein interactions, protein-DNA interactions, and protein-lipid interactions. For example, 3-Hydroxyphenyl-3H-diazirine has been used to study the interaction between the transmembrane domain of the epidermal growth factor receptor (EGFR) and the lipid bilayer. 3-Hydroxyphenyl-3H-diazirine has also been used to investigate the interaction between the tumor suppressor protein p53 and DNA. |
| Future Directions |
One potential direction is the development of new 3-Hydroxyphenyl-3H-diazirine derivatives with improved properties, such as increased reactivity or specificity. Another potential direction is the use of 3-Hydroxyphenyl-3H-diazirine in combination with other photoactivatable reagents, such as azobenzene, to study complex biological processes. Additionally, 3-Hydroxyphenyl-3H-diazirine could be used in combination with other techniques, such as mass spectrometry, to study protein-protein interactions and other biomolecular processes in greater detail. |
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