製品名:4-chloro-5,6-difluoronicotinic acid

IUPAC Name:4-chloro-5,6-difluoropyridine-3-carboxylic acid

CAS番号:851386-32-8
分子式:C6H2ClF2NO2
純度:95%+
カタログ番号:CM132506
分子量:193.53

包装単位 有効在庫 価格(USD) 数量
CM132506-250mg in stock ũǶNJ
CM132506-1g in stock ǜNJȬ
CM132506-5g 1-2 Weeks ȬNJNJ
CM132506-10g 3-4 Weeks ũNJȬũ

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製品詳細

CAS番号:851386-32-8
分子式:C6H2ClF2NO2
融点:-
SMILESコード:O=C(O)C1=CN=C(F)C(F)=C1Cl
密度:
カタログ番号:CM132506
分子量:193.53
沸点:297.1°C at 760 mmHg
MDL番号:MFCD09031172
保管方法:Keep in inert atmosphere, store at 2-8°C.

Category Infos

Pyridines
Pyridine is a six-membered heterocyclic compound containing one nitrogen heteroatom. Pyridine and piperidine are the most frequently occurring heterocyclic building blocks in drug molecules. According to incomplete statistics, there are currently more than 180 drugs containing pyridine or piperidine structure that have been marketed, nearly 1/5 of the drugs approved for marketing in recent years contain these two structures.
Pyridine | C5H5N | Pyridine Supplier/Distributor/Manufacturer - Chemenu
Pyridine,Pyridine Wholesale,Pyridine for Sale,Pyridine Supplier,Pyridine Distributor,Pyridine Manufacturer
Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell.

Column Infos

IAG933
IAG933 is a potent, selective, and first-in-class inhibitor from Novartis that directly inhibits the protein-protein interaction (PPI) between YAP/TAZ and TEAD. By blocking this PPI, IAG933 interferes with oncogenic functions downstream of the Hippo signaling pathway, particularly in mesothelioma and other tumors with NF2 loss-of-function mutations or YAP/TAZ fusions. This inhibition reduces transcriptional activity and induces cell death in cancer cells, leading to significant tumor regressions in xenograft models. Additionally, combining IAG933 preclinically with other targeted therapies (i.e., RTK, KRAS-mutant selective, and MAPK inhibitors) shows promise for improving the efficacy and durability of treatment responses. IAG933 is currently being evaluated in a Ph. I trial (NCT04857372) for solid tumors with Hippo pathway alterations.
Chemenu has been working to develop more compounds for drug discovery. Here are the building blocks we can provide.