Benzothiazoles are aromatic heterocyclic compounds with the chemical formula C7H5NS. Benzothiazoles and their derivatives are a very important class of heterocyclic compounds that are ubiquitous in nature and are mainly used in medicine, agriculture and industry. In medicine, benzothiazole derivatives are a kind of very important pharmaceutical intermediates with good pharmacological and biological activities. It can be used as a fungicide, anti-tuberculosis drug, anti-malarial, anti-convulsant, insecticide, sedative and anti-inflammatory drug, and can also be used to treat diabetes and has anti-cancer effects.
Oxadiazoles are a class of heterocyclic aromatic compounds with the molecular formula C2H2N2O, which have special biological activities and thermodynamic properties. Five-membered heterocyclic moieties composed of three or two heteroatoms are of great interest to researchers because these compounds show significant therapeutic potential. These heterocycles can serve as a building block for the development of novel molecular structures.
Benzodioxanes are a class of isomeric compounds with the molecular formula C8H8O2. The three isomers of benzodioxane are 1,2-benzodioxane, 1,3-benzodioxane and 1,4-benzodioxane. 1,4-Benzodioxane has long been a versatile template widely used to design molecules with diverse biological activities. Its use spans past decades in medicinal chemistry to today, involving many drug discovery strategies, not excluding the most advanced ones. 1,4-Benzodioxane derivatives have been described as agonists and antagonists of nicotinic, alpha-adrenergic and 5-HT receptor subtypes. 1,4-Benzodioxane derivatives have been also reported as antitumor and antibacterial agents.
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