cas 939768-64-6|| where to buy cis-tert-Butyl 3-hydroxycyclobutanecarboxylate

製品名:cis-tert-Butyl 3-hydroxycyclobutanecarboxylate

IUPAC Name:tert-butyl (1s,3s)-3-hydroxycyclobutane-1-carboxylate

包装単位	有効在庫	価格（USD）
CM202687-250mg	in stock	Ǒƥ
CM202687-1g	in stock	ŪǑŞ
CM202687-5g	in stock	ǑŞǑ

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: CAS番号:939768-64-6; 分子式:C9H16O3; 融点:-; SMILESコード:O=C([C@H]1C[C@@H](O)C1)OC(C)(C)C; 密度:

: カタログ番号:CM202687; 分子量:172.22; 沸点:; MDL番号:MFCD20259656; 保管方法:Store at 2-8°C.

: Cyclobutanes; The molecular structure of cyclobutane has four carbon atoms, and its four carbon atoms are not in the same plane, which is the folded conformation of cyclobutane. Cyclobutane itself is not of commercial or biological interest, but more complex derivatives are important in biology and biotechnology. Currently, nine FDA-approved drugs contain the cyclobutane structure. From the perspective of therapeutic areas, cyclobutyl drugs are mainly distributed in popular areas such as tumors, neurological diseases, infectious diseases, endocrine and metabolic diseases.

: DNL343; Denali Therapeutics announces completion of enrollment for regimen G evaluating eIF2B agonist DNL343 in the phase 2/3 HEALEY ALS platform trial. Amyotrophic lateral sclerosis (ALS) causes progressive nerve degeneration in the spinal cord and brain, representing a large unmet medical need. The activation of integrated stress response (ISR) is documented in ALS patients, resulting in the suppression of eukaryotic translation initiation factor 2B (eIF2B) activity, and impaired protein synthesis.
Denali's ALS therapy DNL343 is an investigational small molecule eIF2B activator. It is designed to restore protein synthesis and inhibit ISR pathway in ALS. The compound is found to be generally well-tolerated and support once-daily dosing.