Morpholine contains secondary amine groups and has all the typical reactive characteristics of secondary amine groups. It can react with inorganic acids to form salts, and react with organic acids to form salts or amides, which can be subjected to alkylation reaction, and can also be reacted with ethylene oxide, ketone or Willgerodt reaction. Morpholine is a six-membered ring containing oxygen and nitrogen, and its alkalinity is much lower than that of its parent piperidine. The marketed morpholine drugs are mainly distributed in the fields of tumors, cardiovascular and cerebrovascular diseases, respiratory system diseases, digestive system diseases, infectious diseases and mental disorders.
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Phthalazine is a heterocyclic compound with the molecular formula C8H6N2 composed of a benzene ring fused with a pyridazine ring. Phthalazine and its derivatives do not exist in nature. Phthalazines are used as starting materials for organic synthesis. Studies have found that phthalazine has a variety of physiological activities, such as anti-cancer, antibacterial, anti-inflammatory and so on. The synthesis of phthalazine compounds with novel structures and better biological activities has become a research hotspot in recent years.
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